In aging cells in which the division mechanism is disturbed, an important class of retrotransposons, which is called L1, is out of cell control. He begins to multiply in the cells, it causes inflammatory reactions that extend to neighboring, healthy cells, according to the results of the study.
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Scientists tested six different inhibitor drugs to see if they can block L1 activity. The drug from HIV – lamivudine, stood out noticeably in the research process due to its activity and the absence of side effects.
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Lamivudin reduced L1 activity and suppressed the manifestation of the secretory phenotype, which are identical with aging. In 20-month-old mice, the drug for six months of administration contributed to the disappearance of signs of fat and muscle loss, as well as scarring of the kidneys.
In the future, researchers plan to begin clinical trials involving people who suffer from arthritis and Alzheimer's disease.
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