Researchers from Cardiff University have found an immune T-cell in the blood of people, which ensures the focus of therapy on various types of cancer. The results of the study were published in the journal Nature Immunology.
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One of the main achievements in the fight against cancer in recent years is the development of CAR-T immunotherapy. The technique involves the removal of the patient's T-lymphocytes and their reconfiguration to counter the proteins of specific malignant cell populations. Since 2017, the technique has been used to treat several types of cancer.
However, the problem was the lack of a universal T-cell receptor that could affect different types of cancer.
Detected lymphocytes can make immunotherapy possible against many types of cancer / Photo: Unsplash
Found T cells for universal cancer therapy
Now that scientists have found the immune T cell in people's blood, this will help scan the body and look for potential threats.
It differs from previously discovered methods in that it can attack cancer cells without destroying healthy ones.
The target for these cells is probably the surface molecule MR1. It is present in most human cells, but in malignant cells its structure changes.
Scientists suggest that the method affects the MR1 molecule / Photo: Unsplash
In the future, T cells are planned to be taken from human blood and genetically modified to create a receptor that detects cancer. Then, these cells in large quantities will be returned to patients to fight cancer.
Their use can become the basis of universal immunotherapy, the creation of which was previously considered impossible. Such therapy will be cheaper and more affordable than traditional immunotherapy.